Jan 16, 2020
Leukemia cutis should be high on the differential in patients
presenting with leukemia. Dr. Vincent DeLeo talks with Dr. Lindsay
Strowd and Wasim Haidari about their research on the
presentation of leukemia cutis and clinical implications. “For
us as dermatologists, to recognize that you may not know that the
patient has leukemia at the time that you’re actually evaluating
them I think points to the need to biopsy any spots that look
unusual or a little bit different in nature,” notes Dr. Strowd.
We bring you
the latest in dermatology news and research:
Oral lichen planus prevalence estimates go global
- Dr. Daniel Siegel discusses the translational science
behind natural ingredients
Things you will learn in this episode:
- Leukemia cutis tends to present in patients with acute myeloid
leukemia (AML) but also can present in other forms of the
- Clinically, leukemia cutis is thought to present most commonly
as solitary nodules, but recent research revealed that the primary
presentation may include multiple papules or other unusual
presentations such as mucosal and ulcerative lesions.
- Thorough and comprehensive full skin examinations are important
in patients with leukemia: “Biopsy for leukemia cutis certainly is
most times diagnostic for the disease, but I think paying attention
to the entire skin surface of a patient with leukemia is also
vitally important because [lesions] are not always going to present
on the trunk or the arms or legs where they’re easily identifiable.
Some of our patients have lesions on the scalp, the mucosal
surfaces like the oral mucosa, and in the genital region as well,”
says Dr. Strowd.
- Leukemia cutis can present at various stages during the course
of leukemia, and time to diagnosis varies depending on subtype. For
AML, study results indicated that the average interval between
diagnosis of leukemia and leukemia cutis was about 5 months;
however, many patients developed cutaneous findings at the onset of
leukemia or with relapse.
- Leukemia cutis is considered a negative prognostic factor and
may be associated with a shorter overall mortality in leukemia
- It is important for dermatologists to have a good close working
relationship with their oncology colleagues to facilitate prompt
evaluation of leukemia patients who may present to their oncologist
or another specialist with cutaneous findings.
Hosts: Elizabeth Mechcatie; Terry Rudd; Vincent A.
DeLeo, MD (Keck School of Medicine of the University of Southern
California, Los Angeles)
Guests: Lindsay Strowd, MD, and Wasim Haidari,
BS, BA (Wake Forest School of Medicine, Winston-Salem, North
Show notes by: Alicia Sonners, Melissa Sears, Elizabeth
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